When you've exhausted all avenues, and expressed to the Lord your desires, there may come a time where you need to consider that His will for you may be a "new beginning".
As hard as that may be to accept, you must trust God with all your heart and lean not on your own understanding (Proverbs 3:5). Have faith that the Lord can create good out of what seems exceedingly bad. More than ever, continue to seek His guidance as you begin this next chapter of your life, as He is not out to harm you, but to give hope and a future (Jeremiah 29:11).
“Remember not the former things, nor consider the things of old. Behold, I am doing a new thing; now it springs forth, do you not perceive it? I will make a way in the wilderness and rivers in the desert." (Isaiah 43:18-19)